DNA Music – Sequencing Protein TSPO Transcript
You are listening to the assembly melody of the protein sequence from the human TSPO gene
Homo sapiens translocator protein (18 kDa), TSPO, transcript variant PBR-S, mRNA
Introduction
As part of the Adaris Genome Music Project, we continue transforming biological processes into sonic structures. This time, the object of sound interpretation is the protein sequence encoded by the TSPO gene – translocator protein with a mass of 18 kDa, present in the mitochondrial membrane.
TSPO plays an important role in regulating cellular energy, cholesterol transport, stress response, and immune signaling. But if we translate its amino acid sequence into the language of music, we can hear the rhythm of molecular biosynthesis the “sounded” work of the ribosome.
How the TSPO Melody Is Born
Each amino acid has its unique chemical and structural character. In the “Genome Melody” musical model, each amino acid is translated into a separate note or chord, while the type of physicochemical properties determines the choice of instrument, register, and rhythm.
Musical interpretation scheme:
- Hydrophobic amino acids → low notes, warm timbres (cello, bass guitar)
- Polar residues → middle register (piano, synthesizer)
- Charged amino acids → bright high notes (violin, flute)
- Start and stop codons → sound markers for phrase beginning and completion
Thus, the TSPO sequence transforms into a musical composition reflecting the structure and rhythm of protein assembly on the ribosome.
TSPO – A Protein That Sounds Like Cellular Energy
The translocator protein is located in the outer membrane of mitochondria the cell’s power stations.
The PBR-S transcript (one of the TSPO mRNA variants) defines a unique amino acid pattern that, when translated into music, creates:
- Pulsating rhythm reminiscent of mitochondrial transport activity
- Repeating motifs corresponding to transmembrane regions
- Bright melodic bursts corresponding to charged amino acids involved in regulatory interactions
This makes TSPO’s sound similar to the music of movement, energy, and metabolism.
What Are You Hearing?
The musical composition based on the TSPO protein sequence is not just an artistic interpretation. It is a sonic representation of a real biological process, where each note represents an amino acid and each phrase corresponds to a stage of protein assembly in the ribosome.
This sound structure reflects:
- The dynamics of translation
- The structure of mitochondrial protein
- TSPO’s energetic character
- Its functional domains
- The rhythm of biosynthesis existing inside every human cell
Genetic Source
Homo sapiens translocator protein (18kDa) (TSPO), transcript variant PBR-S, mRNA